Microneedling in Portland | Collagen Induction Therapy | Be Smooth
Microneedling /
Collagen Induction Therapy
Microneedling is one of the most effective skin rejuvenation treatments available — and at Be Smooth in Portland's Pearl District, we've elevated it with the most advanced infusion options on the market. Whether you're targeting fine lines, acne scarring, uneven texture, or enlarged pores, our microneedling treatments stimulate your skin's own natural repair process for results that improve with every session.
Microneedling — also known as Collagen Induction Therapy — uses a professional device with fine needles to create microscopic channels in the skin. These controlled micro-injuries trigger the skin's natural healing response, stimulating the production of collagen and elastin and releasing the body's natural repair messengers — cytokines and growth factors — deep within the skin.
The result is firmer, smoother, more even-toned skin that continues to improve in the weeks following each session.
What microneedling treats
Fine lines and wrinkles
Acne scarring and enlarged pores
Uneven skin tone and texture
Hyperpigmentation and sun damage
Skin laxity and loss of firmness
Dull, tired-looking complexion
We offer two options for this complete treatment including:
Microneedling with Infusion of Stem Cell Growth factor and /or Exosomes or PDRN followed by LED light therapy
Face: $ 250
Face and Décolleté: $ 290
At Be Smooth, we offer microneedling with advanced infusion therapy for enhanced results.
Every session includes LED light therapy to accelerate healing and maximise collagen production.
For optimal results, we recommend a series of three treatments, spaced four to six weeks apart.
When you book your initial session, you can enjoy $15.00 off the second treatment and $20 off the third (and any additional sessions)
What are Exosomes?
Exosomes are tiny vesicles — natural messengers produced by stem cells — that carry powerful signals between cells to trigger the body's healing and regeneration responses.
At Be Smooth, we use a concentrated exosome solution derived from human stem cells, guaranteed to contain 10 billion exosomes per vial. Rich in growth factors, peptides, and proteins, exosomes deliver potent rejuvenating signals directly into the skin channels created by microneedling. They accelerate healing, promote collagen production, decrease inflammation, and improve skin texture, tone, and elasticity.
Exosomes are mixed with hydrating hyaluronic acid for an additional layer of deep skin nourishment during your session.
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Faster, more intense results: Exosomes, which are signaling vesicles containing a cocktail of growth factors, lipids, and RNA, are known to deliver faster, more powerful results than PDRN.
They are ideal for rapid post-procedure healing and for those who want a quicker, visible improvement in skin radiance, texture, and pigmentation.Comprehensive regeneration: With a diverse payload of biomolecules, exosomes can stimulate multiple cellular pathways at once.
This results in enhanced effects beyond collagen production, such as boosts to elastin and hyaluronic acid levels.
High-tech reputation: Exosomes are considered a "next-generation" regenerative therapy, and some may opt for them due to the advanced technology and higher potency associated with the treatment.
What is PDRN?
PDRN (Polydeoxyribonucleotide) is a regenerative compound derived from DNA fragments — most commonly from salmon — that has been used in regenerative medicine for decades.
What makes PDRN exceptional is its ability to stimulate tissue regeneration at a cellular level, encouraging your skin to repair itself more efficiently. When infused during microneedling, PDRN amplifies the treatment's collagen-boosting effects and supports faster, more visible results.
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Slow and Gradual but Consistent Regenerative Effects.
Safety and established history: PDRN is a mixture of DNA fragments, most commonly from salmon, and has been used in regenerative medicine for decades with a strong safety record. The rigorous extraction and purification process is designed to eliminate proteins and peptides that could cause an immunological reaction. The potential risk is primarily limited to those with a specific salmon or seafood allergy.
Gentle, long-term repair: PDRN is known for its slow and gradual but consistent regenerative effects. It is an excellent choice for long-term skin health and for individuals with sensitive, inflamed, or damaged skin due to its calming properties.
Targeted healing and hydration: PDRN provides the foundational materials—nucleotides and deoxyribonucleotides—that cells need to repair DNA and build new tissue. It excels at strengthening the skin barrier, boosting hydration, and promoting angiogenesis (the formation of new blood vessels), which is particularly beneficial for scars and aging skin.
Anti-inflammatory properties: By activating the adenosine A2A receptor, PDRN is an effective anti-inflammatory agent that reduces redness and irritation
PDRN is generally well-tolerated by most skin types, including sensitive or compromised skin. Since it’s a biologically active ingredient, products undergo rigorous purification processes to ensure safety. It’s ideal for:
People in their late 20s and above concerned with ageing or dullness
Individuals with compromised barriers or reactive skin
Anyone looking to enhance overall skin health and repair
What To Expect From Your Microneedling Session
Your microneedling appointment at Be Smooth begins with a full consultation and skin preparation. A topical numbing cream is applied for your comfort before treatment begins. Your esthetician will then perform microneedling using a professional-grade device, followed by infusion of your chosen serum — Exosomes or PDRN — and LED light therapy to support healing.
After your session, your skin may look pink and warm, similar to a mild sunburn. This is a normal part of the healing process and typically fades within 1–2 days. As your skin continues to heal over the following weeks, you'll notice visible improvements in tone, texture, and brightness.
Keep your skin clean, moisturised, and out of direct sunlight while it heals.
Frequently Asked Questions
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Most clients experience minimal discomfort and they describe the sensation as a mild tingling.
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Most clients experience redness and mild swelling for 1–2 days following treatment. You can return to normal daily activities immediately, though we recommend avoiding heavy exercise, saunas, and direct sun exposure for 48 hours.
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Many of our Portland clients combine microneedling with other services at Be Smooth. Your esthetician will advise which combinations are appropriate for your skin and timing between treatments.
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Microneedling is generally safe for most skin types. During your consultation, your esthetician will assess your skin and confirm whether microneedling is the right treatment for you.
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When performed by a trained esthetician, microneedling is a very safe procedure. Temporary redness, mild swelling, and sensitivity are the most common side effects and typically resolve within 1–2 days. We always conduct a full skin assessment before treatment to ensure suitability.
Ready to invest in your skin?
To Book your microneedling session Click here
or call us at (503) 360-1178.